Prothena Biosciences
Feb 01, 2018
Background:
The heart rate (HR) response to paced deep breathing (DB) is a common test of cardiac autonomic function, where high heart rate variability (HRV) is…
Jan 21, 2018
Background:
Chronic physical illness has been associated with emotional distress. Chronic diseases may change usual family patterns with economic, social and family…
Hereditary ATTR amyloidosis is an inherited genetic disease in which there is thickening and stiffening of the heart muscle, due to a build-up of abnormal protein.…
Jan 17, 2019
Hereditary transthyretin-mediated amyloidosis is caused by a mutation in transthyretin (TTR) gene resulting in misfolded TTR protein accumulating as amyloid fibrils…
Hereditary ATTR amyloidosis is an inherited genetic disease which variably affects the nervous system and the heart. Hereditary ATTR amyloidosis was traditionally…
Transthyretin amyloidosis is a slowly progressive condition characterized by the buildup of abnormal deposits of a protein called amyloid (amyloidosis) in the body'…
Background:
Hereditary transthyretin amyloidosis (ATTR) is usually characterised by a progressive peripheral and autonomic neuropathy often with associated cardiac…
May 26, 2015
Background:
A recent 2-year randomized controlled trial indicated that the transthyretin (TTR) tetramer stabilizer, diflunisal, inhibits polyneuropathy progression…
Nov 30, 2015
Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with…
Nov 26, 2015
Transthyretin (TTR) amyloidosis (ATTR amyloidosis) is a multisystemic, multigenotypic disease resulting from deposition of insoluble ATTR amyloid fibrils in various…