Scientific Articles

Extract A 76-year-old woman was found to have abnormally enlarged and calcified bilateral axillary lymph nodes on a screening mammogram (Figure 1). These…

Cardiac amyloidosis used to be considered an ultra-rare disease with no treatment options. No longer. Advances in noninvasive testing have led to greater awareness…

IntroductionTransthyretin amyloidosis (ATTR) is a progressive, heterogeneous rare disease manifesting as ATTR polyneuropathy (ATTR-PN), ATTR cardiomyopathy (ATTR-CM…

AL amyloidosis is caused by the excessive production of nonfunctional immunoglobulins, leading to the formation of amyloid fibrils that damage vital organs,…

About the episodeIn this video, Prof Philip Hawkins (University College London, London, UK), addresses some important key questions surrounding amyloidosis, a…

AimsHELIOS-A was a Phase 3, open-label study of vutrisiran, an RNA interference therapeutic, in patients with hereditary transthyretin (ATTRv) amyloidosis with…

BackgroundTransthyretin cardiac amyloidosis (ATTR‐CA) is a progressive and ultimately fatal cardiomyopathy. Biomarkers reflecting multiorgan dysfunction are of…

BackgroundTafamidisexternal link, opens in a new tab was approved to treat patients with transthyretinexternal link, opens in a new tab amyloid…

Disease OverviewImmunoglobulin light chain amyloidosis is a clonal, nonproliferative plasma cell disorder in which fragments of immunoglobulin light or heavy chain…

Abstract:Transthyretincardiac amyloidosis is a rare disease that has gained significant attention in recent years because of misfolding of transthyretin fibrils…