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Introduction: Wild-type transthyretin amyloidosis (ATTRwt amyloidosis) is a progressive disease resulting from the accumulation of wild-type transthyretin (TTR)…

Transthyretin (TTR) is a tetrameric protein synthesized mostly by the liver and secreted into the plasma. TTR molecules can misfold and form amyloid fibrils in the…

What Is This Plain Language Summary About? This plain language summary describes some results of a study called ATTR-ACT. This was the first large study to include…

Background: Bone marrow biopsy is common in patients suspected of having systemic AL amyloidosis. However, little is known about the incidence, morphology and…

Genetic counseling gives you information about how genetic conditions might affect you or your family. A genetic counselor will educate you on the process and…

Rationale & Objective: Test the feasibility of replacing 24-hour urine collection with a single voided urinary protein-creatinine ratio (UPCR) in patients with…

Although life with amyloidosis can present a variety of challenges, people diagnosed with the condition can experience productive and fulfilling lives by…

The European Hematology Association (EHA) and International Society of Amyloidosis (ISA) recently agreed to collaborate on the development of guidelines for high-…

Background: Tafamidis is approved in many countries for the treatment of transthyretin amyloid cardiomyopathy. This study reports data on the long-term efficacy of…

AL amyloidosis is a systemic amyloidosis and is associated with an underlying plasma cell dyscrasia. High dose intravenous melphalan and autologous stem cell…