Nov 11, 2024
Background: Advancements in diagnostics and increased awareness have led to higher identification of cardiac amyloidosis. This condition, characterized by the…
Nov 09, 2024
Hereditary transthyretin amyloidosis (ATTRv) is a rare autosomal dominant adult-onset disorder caused by point mutations in the transthyretin (TTR) gene encoding…
Sep 19, 2024
Brief SummaryThe purpose of this study is to characterize cardiac safety of Daratumumab, Cyclophosphamide, Bortezomib, and Dexamethasone (D-VCd) treatment regimens…
Jun 23, 2024
Hereditary transthyretin amyloidosis (ATTR) is an autosomal dominant, life-threatening genetic disorder caused by a single-nucleotide variant in the transthyretin…
Apr 23, 2024
Rare diseases (RD) affect a small number of people compared to the general population and are mostly genetic in origin. The first clinical signs often appear at…
Apr 09, 2024
The immediate goal for therapy in patients with systemic immunoglobulin light chain amyloidosis (AL) is to swiftly achieve at least a hematologic very good partial…
Jan 18, 2024
Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is an underrecognized cause of heart failure due to misfolded wild-type transthyretin (TTRwt) myocardial…
Jan 03, 2024
BackgroundStakeholders increasingly expect research and care delivery to be guided by and to optimize patient experiences. However, standardized tools to engage…
Mar 22, 2022
Transthyretin (TTR) is a tetrameric protein synthesized mostly by the liver and secreted into the plasma. TTR molecules can misfold and form amyloid fibrils in the…
Jun 18, 2018
Aims: Wild-type transthyretin (ATTRwt) cardiac amyloidosis has emerged as an important cause of heart failure in the elderly. Atrial fibrillation (AF) commonly…