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AbstractAmyloid light-chain (AL) amyloidosis is characterized by the deposition of amyloid fibrils in various organs, although gallbladder involvement is rare. We…

AbstractBackgroundLeft atrial appendage occlusion (LAAO) is a valuable alternative therapy to anticoagulants for stroke prevention, and a representative study has…

Loneliness is a neuropsychiatric symptom that has been associated with cognitive impairment and dementia. We aimed to investigate whether depressive symptomatology…

ObjectiveIdentification of clinically meaningful subphenotypes of disease progression can enhance the understanding of disease heterogeneity and underlying…

PurposeAccording to a WHO statement, it has been asserted that there is no safe level of alcohol consumption regarding human health. Nevertheless, the relationship…

AbstractThe progressive number of old adults with cognitive impairment worldwide and the lack of effective pharmacologic therapies require the development of non-…

Key PointsQuestionWhat is the safety, tolerability, and efficacy of N-acetylcysteine (NAC) for patients with hereditary cystatin C amyloid angiopathy (HCCAA)?…

AbstractThe amyloid hypothesis has been a leading narrative concerning the pathophysiological foundation of Alzheimer’s and Parkinson’s disease. At the two ends of…

AbstractYears of experience watching our patients progressively decline and die from complications of Alzheimer's disease (AD) has strongly motivated us to provide…

AbstractIntroductionThis prospective observational study of patients with transthyretin amyloid cardiomyopathy (ATTR-CM) undergoing treatment with tafamidis aims at…