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In some patients with amyloidosis there is a build-up of amyloid deposits in the heart muscle. This may cause no symptoms at all if there is just a small amount of…

The understanding of why and how proteins misfold and aggregate into amyloid fibrils has increased considerably during recent years. Central to amyloid formation is…

Amyloidosis results from protein misfolding, and ongoing amyloid deposition can ultimately lead to organ failure and death. Historically, this is a group of…

AA amyloidosis was previously known as secondary amyloidosis, or reactive systemic amyloidosis. It occurs in patients who have suffered from prolonged, chronic…

Background: In published case reports, tocilizumab (TCZ) has shown good efficacy for AA amyloidosis in almost all patients. We investigated the efficacy and safety…

Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory syndrome. FMF is caused by mutations in the MEFV gene which encodes the pyrin…

Background: Hereditary transthyretin amyloidosis (ATTR) is usually characterised by a progressive peripheral and autonomic neuropathy often with associated cardiac…

The term "amyloids" refers to fibrillar protein aggregates with cross-b structure. They have been a subject of intense scrutiny since the middle of the previous…